The onset for symptoms in this diagram is about 10 years of age on average and that is a retrospect. The average age for starting treatment for Fabry Disease is right around 38 to 40 years old. That is potentially a problem for a disease that’s continuously adding to the damage to the body. One of the roles of the pediatrician is to make sure that they recognise Fabry Disease at the point where the symptoms are having their first onset and that would allows us to intervene and hopefully prevent the more serious complications that are happening. Also notable is the age for renal problems, heart problems and strokes comes right about the same age as the initiation of therapy, which is clearly not ideal.